Portfolios Archive • Page 6 of 7 • National Imaging Facility

Inquiries

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Paul Parizel

UWA Node Director

Tim Rosenow

UWA Facility Fellow

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Biograph MR-PET (large bore) Monash

Biograph MR-PET (large bore)

The Biograph MR-PET is a fully integrated 600mm bore 3T MRI and PET system. This allows for the simultaneous acquisition of PET data with the soft tissue discrimination of MRI. As MRI emits no ionising radiation PET scans can be performed for a longer duration allowing higher accuracy. All data is fully integrated with kinetic and standard reconstructions covering the whole body if required.

40% greater sensitivity then PET-CT
High MR image quality for off-centre imaging, fat saturation and spectroscopy
32″ BOLDScreen for stimuli presentation
Two CCTV cameras in scan room with wide angle coverage
Range of application suites for optimised examinations of all regions

Inquiries

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Monash Facility Fellow

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BioFLECT Monash

FLECT-CT

The TriFoil FLECT-CT small animal imaging system is located at the Monash Insitute for Pharmaceutical Sciences (MIPS – Parkville). The TriFoil FLECT-CT instrument provides in vivo optical imaging with uniform sensitivity and resolution throughout the object. The system provides images of deep tissue phenomena without loss of image or quantitative accuracy. The X-ray CT scanner provides co-registered images for anatomical correlation that significantly improves the segmentation and resolution of the optical images.

The system is capable of imaging rodent animal models with axial and transaxial fields of view of 38mm and 100mm (mice), and 42 frequency excitation options, up to 16 light filtration options, and is configured with “InVivoScope” control and analysis software.

FLECT system capable of imaging in the range of ~500 – 870 nm
Individualised animal tissue heterogeneity map for compensation/correction of attenuation of photons based on CT image
Deep tissue algorithms for fluorescence recovery based on individualised geometry of each animal
Ability to plug-in imaging cells compatible with MRI, and to fuse FLECT, CT, and MRI images
Diffusion MRI
Simultaneous fMRI and EEG

Inquiries

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Monash Facility Fellow

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9.4T MRI Small Animal Monash-ARAMBI

9.4T MRI Small Animal

The 9.4T animal magnetic resonance imaging (MRI) system (Bruker) located at the ARA-MBI campus in Prahran is optimised for rodent and high-resolution sample imaging. The ultra high magnetic field coupled with rodent cryocoils provides structural and functional images with higher resolution and signal to noise ratio compared with standard MRI. This scanner can be used for brain, abdominal, cardiovascular, muscular and articular, as well as dynamic molecular imaging.

Small animal imaging studies
Mouse and rat cryocoils for brain and whole body imaging
Mouse and rat cardiac surface coils for heart imaging
40 mm 19F fluorine imaging coil for use with rodents or samples
35 mm volume coil for high-resolution mouse head or sample imaging
86 mm radio frequency transmit and receive coils
Suitable isofluorane anaesthesia and animal monitoring system
Full range of beds to cater for more species and samples

Inquiries

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Robert Brkljača

Facility Manager

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Gary and Karine using the MRI. Image courtesy of CAI, UQ

9.4T MRI Small Animal UQ

9.4T MRI Small Animal

The Bruker Biospec MRI scanner consists of a 9.4 Tesla, 300 mm ultrashield refrigerated 30 cm magnet interfaced to a scalable Bruker Avance III spectrometer that allows unparalleled flexibility for MRI scanning of small and medium sized research animals and other samples.

The system incorporates a cryoprobe, which enables maximum signal and image quality to be achieved for rodent mouse brain imaging. The system also includes 8 parallel RF transmit and receive channels for multi-coil phased array imaging and numerous coils to investigate nuclei other than standard protons or “water” imaging, notably carbon-13 coils to investigate metabolism, sodium-23 coils to investigate cell viability, phosphorus-31 coils to investigate tissue energetics and fluorine-19 coils for labelling of targeted tracers.

Cryoprobe for rodent and mouse imaging
C-13, Na-23, P-31 and F-19 coils
MR Spectroscopy (MRS)

QLD Node Info

Inquiries

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Markus Barth

Queensland Node Co-Director

Gary Cowin

QLD Facility Fellow

Nyoman Kurniawan

Research Fellow, CAI

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9.4T MRI Small Animal UNSW

9.4T MRI Small Animal

The MRI facility at the UNSW’s BRIL is one of the most powerful small-animal MRIs in Australia and is able to provide users with state-of-the-art small animal and sample imaging, and MRI biomarker assessment.

Structural, physiological, and metabolic imaging studies
Small rodent monitoring, anaesthesia, and positioning systems
High power gradient system (wide bore)
High power gradient insert (micro-imaging)
Various coils; cryo-cooled, standard, x-nucleus

UNSW Node Info

Inquiries

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Andre Bongers

UNSW Facility Fellow

Carl Power

UNSW - BRIL Node Director

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9.4T MRI Small Animal Monash

9.4T MRI Small Animal

The 9.4T animal MRI system (Agilent/Bruker) housed at the Clayton site is a flexible and adaptable magnetic resonance imaging scanner for pre-clinical imaging and research. The system runs Paravision 6 and can carry out a wide range of pre-clinical imaging functions with a range of proton coils for various applications. The ultra high magnetic field provides structural and functional images with higher resolution in comparison with clinical MRI. It can be used for brain, abdominal, cardiovascular, muscular and articular, as well as dynamic molecular imaging.

Anatomical imaging studies
Animal beds for rodents and marmosets
Horizontal bore magnet with 205/120 gradient coils
Phased array surface coils for rat and mouse brain and heart
200 mm surface coils for 1H-19F (370-420 MHz), 31P-13C (75-170 MHz), 2H-15N (39-82 MHz)
40 mm 190-F coil for rodents

Inquiries

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Monash Facility Fellow

Gang Zheng

Monash Facility Fellow

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7T MRI Whole Body UQ

7T MRI Whole Body

Aiman operating the 7T MRI with a humna subject. Image courtesy of CAI, UQ.

Key technical features of the Siemens Magnetom 7T MRI system include high-performance gradients and multi-receive and multi-transmit radiofrequency capabilities that further increase sensitivity.

The 7T is utilised across a broad range of applications, including neuroscience, engineering, spectroscopy and theranostics. Alzheimer’s and Parkinson’s diseases, Multiple Sclerosis, epilepsy, musculoskeletal and liver diseases are examples of clinical applications that benefit from the high spatial resolution achievable with this instrument.

Anatomical imaging studies
Functional MRI (fMRI)
High-performance gradients
Multi-receive and multi-transmit radio-frequency capabilities

QLD Node Info

Inquiries

To the Node

Markus Barth

Queensland Node Co-Director

Aimann Al Najjar

Head of Human & Companion Animal Imaging Operations, CAI

4DX Pulmonary Imaging System LARIF

4Dx Permetium Pulmonary Preclinical Imaging System

The 4Dx preclinical scanner is a small animal research scanner which uses x-rays and computed tomography capabilities to measure respiratory function in small rodents.

Preclinical lung imaging system
No contrast requirement
Cardiac and pulmonary gating capabilities

Inquiries

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Chris Christou

SAHMRI Node Co-Director

Georgia Williams

SAHMRI Facility Fellow

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3T Skyra MRI (large bore) Monash

3T Skyra MRI (large bore)

The Siemens 3 Tesla Skyra MRI scanner has a 70cm wide bore, a full range of imaging coils including an advanced 32-channel head coil, a 20 channel head and neck coil, a 32 channel spine coil, and an 18 channel body coil.

The scanner console includes advanced reconstruction and analysis software for functional and diffusion neuroimaging, perfusion imaging, flow quantification, cardiovascular, musculoskeletal electronencephalography system and an SR Instruments eye tracking unit.

Scanner uses XQ Gradients and has multinuclear spectroscopy and parallel transmit technology (ZOOMit) applications.

Neuroimaging and neuropsychological testing
Functional MRI (fMRI)
Flow quantification
Perfusion MRI
Diffusion MRI
Simultaneous fMRI and EEG
MR-compatible pulse oximeter

Inquiries

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