The Australian Epilepsy Project (AEP) will change the lives of people living with epilepsy by reducing uncertainty surrounding diagnosis and fast-tracking the path to optimal treatment using the combination of advanced imaging, genetics, cognition, and artificial intelligence. Such improvements will result in better outcome prediction at disease onset, a higher rate of seizure freedom, reduced economic burden of disease and will increase life-participation of people with epilepsy.Read More
The Australian Government’s National Collaborative Research Infrastructure Strategy (NCRIS) exists to enable national-scale research facilities, thereby facilitating Australian researchers to address critical national and global challenges effectively and efficiently. NCRIS projects provide equipment, resources, analysis tools and, importantly, expertise.Read More
MRtrix3: Advanced tools for the analysis of diffusion MRI data
Diffusion-weighted MRI (dMRI) is a commonly-used medical imaging modality for the investigation of tissue microstructure, exploiting the local hindrance and restriction of water diffusion as indirect probes. The neuroimaging research community utilises this technology extensively for the study of brain white matter in particular, reconstructing structural connectivity pathways and analysing estimated tissue properties.Read More
Head injuries, including concussion, are taken very seriously in sporting professions. To date, making an accurate diagnosis of acute concussion has been made difficult by the lack of a reliable direct biomarker for injury and recovery. This diagnostic gap can lead to unknown recovery periods and potentially long-term impacts for athletes.
Researchers at the Florey Institute of Neuroscience and Mental Health set out to understand functional brain changes in professional players in the Australian Football League who had been diagnosed with acute sport-related concussion.
The world-first study, published in the Journal of Concussion, utilised NIF infrastructure, the 3T Trio and Skyra MRI scanners, and NIF expertise, Facility Fellows Shawna Farquharson and David Abbott.
Functional MRI (fMRI) was undertaken to assess functional connectivity alongside anatomical imaging. Although no anatomical damage was observed, the authors described a decreased intrinsic fMRI connectivity within the right frontoparietal regions in acutely concussed footballers. In other words, all 20 concussed athletes showed reduced activity in parts of the brain responsible for executive function, working memory and switching tasks.
“By looking at how the different parts of the brain talk to each other, we can see how these three brain networks are affected, and these changes may help explain the symptoms we see in concussed players.” – Dr Mangor Pedersen, study co-author, from the Florey Institute of Neuroscience and Mental Health.
One interesting finding in this study is that concussion appears to affect particular networks in the brain. These findings are in agreement with some of the typical clinical features of concussion; however, they are based on trends seen as a group. In future, the authors intend to investigate individual brain networks and develop guidelines for personalised treatment and recovery.
More information about concussion is available here, or by speaking to your GP.