Cancer research will advance and personalised treatment will come a step closer, with installation of NIF’s new nanoScan PET/MRI 3T camera for preclinical studies.
The camera is at the Olivia Newton-John Cancer Research Institute (ONJCRI) and represents a significant national investment as part of NIF expertise and critical mass in molecular imaging and nuclear theranostics.
Nuclear theranostics offers simultaneous imaging and therapy, enabling researchers and clinicians to see where targeted medicines go in the body in real time, identify drugs most likely to succeed and select patients who will benefit.
It has the potential to improve quality of life and decrease health-related costs.
NIF Fellow Dr Ingrid Burvenich from ONJCRI and La Trobe University has conducted MRI scans using the camera as part of work to develop diagnostic tools and cancer therapies.
“We found that the high field 3T magnet has fast scanning times and high-quality images,” Dr Burvenich said.
“We can already see that we have excellent delineation of organs and that will enable us to better identify specific tumours in the brain, abdominal organs and other cancer sites.
“With the new camera, we will be able to explore new areas of cancer biology, metabolism and neuroscience, and also develop new imaging probes and therapeutics.
“In our studies we answer questions such as: does the drug reach the tumour, is enough drug going into the tumour to be effective, and are there risks for toxicity?”
Dr Burvenich’s tumour-targeting work involves collaboration with ONJCRI’s Centre for Research Excellence in Brain Cancer, focusing on research models that reflect the disease as it is seen in human patients.
“We are very excited to try the new camera to image brain tumours to assist with developing new therapeutics.
“Other ONJCRI collaborators are working on genetic models that develop tumours in the stomach or the intestine and surgical models for pancreatic cancer.
“Increasing the visibility of such tumours will potentially make a difference in this research in monitoring how tumours establish, grow and respond to newly-developed therapeutics.
“Our new camera will also assist with advancing research in heart disease, the brain and pharmaceutical drug development – especially in developing radiopharmaceuticals, medicines with radioactive isotopes that can be used as for both diagnosis and treatment.
“We can evaluate the radiopharmaceuticals in preclinical models and then progress them into human trials.”
NIF is investing in improved health outcomes through novel medical products, technologies and practices – including human imaging technologies, high value therapeutics and cutting-edge pharmaceutical treatments.
Nuclear theranostics is increasingly being used for cancer imaging, detection and treatment, in clinical trials, and in research and development to counter a growing global incidence from 19.3 million new cases in 2020 to 28.4 million in 2040.
It has a promising future, with estimated market valuations for 2021 ranging from $1.7 billion to $6 billion and annual growth ranging from 4 to 19 per cent within eight years.