PAST: Fundamentals of Kinetic Modelling workshop

Fundamentals of Kinetic Modelling workshop

Thursday 2 October 2025, 3 – 4:30pm (AEST)

Run by the NIF PET Fellow Network

Speaker: Professor Steven Meikle, Professor of Medical Imaging Physics, University of Sydney.

Audience: NIF PET Fellows, interested researchers and users all welcome

Description:
In this workshop, we will discuss the foundational principles of tracer kinetic modelling, some typical models for various PET tracers and their underlying assumptions, and the most common methods used to estimate the model parameters.

When we introduce a radiopharmaceutical into the human body, it is subject to the same physiological and biological processes as the unlabelled molecule would have undergone had it been administered instead. This is called the tracer principle. The processes that determine the concentration of the tracer in tissue and blood at any point in time include regional blood flow, extraction from the blood into the interstitial space, cellular uptake and clearance, and metabolism. The cellular components of uptake and clearance are controlled by enzymatic activity and/or cell surface receptors. Kinetic models are used in conjunction with dynamic PET to describe these processes and quantify relevant physiological parameters.

Workshop materials:

Google Colab notebook (participants can use this directly without installation): Colab link

CSV files: really_noisy_data noisy_FDG_data Fallypride_M6 Fallypride_M3