MRI in the Study of Animal Models of Neurodegenerative Diseases

Available first online: 17 January 2018


Nyoman D. Kurniawan at the Centre for Advanced Imaging, The University of Queensland, St. Lucia, Australia. N.K. thanked the Queensland Government and Australian Federal Government for funding and operational support of the 16.4T NMR spectrometer through the QLD NMR Network (QNN) and the National Imaging Facility (NIF).

Magnetic Resonance Imaging (MRI) is an important tool to study various animal models of degenerative diseases. This chapter describes routine protocols of T1-, T2-, and T2*-weighted and diffusion-weighted MRI for rodent brain and spinal cord. These protocols can be used to measure atrophy, axonal and myelin injury and changes in white matter connectivity.

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